Human Osteoblast-like Cells Are Permissive for Zika Virus Replication
نویسندگان
چکیده
منابع مشابه
Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication
Zika virus (ZIKV) is an emerging mosquito-borne (Aedes genus) arbovirus of the Flaviviridae family. Although ZIKV has been predominately associated with a mild or asymptomatic dengue-like disease, its appearance in the Americas has been accompanied by a multi-fold increase in reported incidence of fetal microcephaly and brain malformations. The source and mode of vertical transmission from moth...
متن کاملHuman Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus
Zika virus (ZIKV) is a recently re-emerged flavivirus transmitted to humans by mosquito bites but also from mother to fetus and by sexual intercourse. We here show that primary human endometrial stromal cells (HESC) are highly permissive to ZIKV infection and support its in vitro replication. ZIKV envelope expression was detected in the endoplasmic reticulum whereas double-stranded viral RNA co...
متن کاملFormation in Isolated Human Osteoblast-Like Cells
The effect of bradykinin on prostaglandin E 2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 #tool/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding ...
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Zika Virus (ZIKV) is a flavivirus that has been implicated in causing brain deformations, birth defects, and microcephaly in fetuses, and associated with Guillain-Barre syndrome. Mechanisms responsible for transmission of ZIKV across the placenta to the fetus are incompletely understood. Herein, we define key events modulating infection in clinically relevant cells, including primary placental ...
متن کاملUltrastructural Characterization of Zika Virus Replication Factories
A global concern has emerged with the pandemic spread of Zika virus (ZIKV) infections that can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand RNA virus replicating in virus-induced membranous replication factories (RFs). Here we used various imaging techniques to investigate the ultrastructural details of ZIKV RFs and their relationship with host cell organ...
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ژورنال
عنوان ژورنال: The Journal of Rheumatology
سال: 2018
ISSN: 0315-162X,1499-2752
DOI: 10.3899/jrheum.170835